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基本信息:

姓名: 李曉明
職務: 浙江大學醫學院常务副院长、医学院神經生物學系系主任、浙江大学神经科學研究所常务副所长
職稱: 教授
學曆: 博士
專業: 神經生物學
所屬院系: 基礎醫學系
研究方向: 神經生物學方向(理学):1、突觸和神經環路(特別是GABA和彌散性調制系統)的發育、調控和在情感中的作用2、癫痫、睡眠、精神分裂症等神經精神疾病的發病機制;神經病學方向(臨床醫學):癫痫、睡眠、精神分裂症等神經精神疾病的基礎與臨床研究
電話: 0571-88208757
信箱: lixm@zju.edu.cn
個人主頁:

個人簡介:

  李曉明,医学博士、浙江大学教授、多伦多大学教授。教育部“长江学者”特聘教授、中组部国家“万人计划”创新领军人才、国家杰出青年基金获得者。现任浙江大學醫學院常务副院长、医学院神經生物學系系主任、浙江大学神经科學研究所常务副所长等。2003年毕业于原第一军医大学,获医学博士学位,多年来从事神经系统疾病的临床、教学和科研工作,作为课题负责人在研课题有国家自然科学基金重点项目、重大研究计划集成项目等。作为主要完成人获得国家自然科学奖二等奖、省科技进步奖一等奖、中华医学科技奖二等奖、高校科研成果二等奖等奖项。李曉明博士实验室的长远目标是通过对不同神经突触和神經環路的研究,寻求治疗神经精神疾病如精神分裂症、孤独症以及癫痫等的靶分子并提供相应的治疗策略。在突触和神經環路的发育和分子调控领域,尤其在精神分裂症、癫痫等疾病的发病机制方面取得重要研究成果。代表性论文以通讯作者发表在国际著名杂志如《Nature Medicine》、《Nature Neuroscience》、《Neuron》、《Cell Research》、《Elife》、《Journal of Neuroscience》等上,并被国际同行发表专文正面评述。??

研究和招生方向:

通過對不同神經突觸和神經環路的研究,尋求治療神經精神疾病如精神分裂症、孤獨症以及癫痫病等的靶分子並提供相應的治療策略。

神經生物學方向(理学):

1、突觸和神經環路(特別是GABA和彌散性調制系統)的發育、調控和在情感中的作用

2、癫痫、睡眠、精神分裂症等神經精神疾病的發病機制

神經病學方向(臨床醫學):

癫痫、睡眠、精神分裂症等神經精神疾病的基礎與臨床研究

代表性論文:

1.Dong P, Wang H, Shen XF, Jiang P, Zhu XT, Li Y, Gao JH, Lin S, Huang Y,      He XB, Xu FQ, Duan SM, Lian H, Wang H, Chen JD, Li XM*. Thalamic reticular      nucleus circuits for flight behavior. Nature Neurosci. Accepted. (2019)

2.Shen CJ, Zheng D, Li KX, Xie Y, Fu JY, Yu XD, Pan HQ, Li JR, Duan Sm,      Hu HL, Li XM*. Cannabinoid CB1 receptors in the amygdalar cholecystokinin glutamatergic      afferents to nucleus accumbens modulate depressive behavior. Nature      Medicine,25(2):337-34.(2019)

3.Li Y, Li CY, Xi W, Jin S, Wu ZH, Jiang P, Dong P, He XB, Xu FQ, Duan      SM, Zhou YD, Li XM*. Rostral and Caudal Ventral Tegmental Area      GABAergic Inputs to Different Dorsal Raphe Neurons Participate in Opioid      Dependence. Neuron., 101(4):748-761. (2019)

4.Yang JM, Shen CJ, Chen XJ, Kong Y, Liu YS, Li XW, Chen Z, Gao TM, Li XM*. Erbb4 Deficits in Chandelier      Cells in the Medial Prefrontal Cortex Confer Cognitive Dysfunctions: Implications      for Schizophrenia. Cerebral Cortex., 22.doi: 10.1093(2018)

5.Cao SX, Zhang Y, Hu XY, Hong B, Sun P, He HY, Geng HY, Bao AM, Duan      SM, Yang JM, Gao TM, Lian H*, Li XM*. ErbB4 deletion in      noradrenergic neurons in the locus coeruleus induces mania-like behavior      via elevated catecholamines. eLife(2018)

6.Geng HY, Jing Z, Yang JM, Li Y, Wang N, Ye M, Chen XJ, Lian H and Li XM*. Erbb4 Deletion from      Medium Spiny Neurons of the Nucleus Accumbens Core Induces      Schizophrenia-Like Behaviors via Elevated GABAA Receptor α1 Subunit Expression. Journal      of Neuroscience, 37 (31) : 7450-7464 (2017)

7. Zhao CY, Zhang J, Li KX, Yang JM, Yu HM, Duan SM, Jiang KW, Li XM, β-catenin regulates membrane potential in muscle cells through regulation of α2 subunit of Na-K-ATPase. European Journal of Neuroscience, 40(1),2216-24(2014). 

8. Wu HJ, Liu YJ, Li HQ, Chen Q, Dou Y, Lou HF, Ho MS, Li XM, Duan SM, Gao ZH, Analysis of microglial migration by a micropipette assay. Nature protocols, 9,491–500(2014). 

9. Han Y, Shi YF, Xi W, Zhou R, Tan ZB, Wang H, Li XM, Chen Z, Feng G, Luo M, Huang ZL, Duan SM, Yu YQ. selective activation of cholinergic basal forebrain neurons induces immediate sleep-wake transitions. Current Biology, 24(6), 693-8(2014). 

10. Ye M, Yang W, Ainscough JF, Hu XP, Li X, Sedo A, Zhang XH, Zhang X, Chen Z, Li XM, Beech DJ, Sivaprasadarao A, Luo JH, Jiang LH. TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1pyramidal neuronal death after transient global ischemia. Cell Death and Diseases, 27,5:e1541(2014). 

11. Chen C, Li HQ, Liu YJ, Guo ZF, Wu HJ, Li X, Lou HF, Zhu L, Wang D, Li XM, Yu L, Cao X, Lu L, Gao Z, Duan SM. A novelsize-based sorting mechanism of pinocytic luminal cargoes in microglia. Journal of Neuroscience, 33(21),4282-4293.3(2013). 

12. Li, H.Q., Chen, C., Dou, Y., Wu, H.J., Liu, Y.J., Lou, H.F., Zhang, J.M., Li XM, Wang H., Duan S., P2Y4 receptor-mediated macropinocytosis contributes to A?-induced self-uptake by microglia. Molecular Cell Biology, 33(21),4282-4293(2013). 

13. Dou Y, Wu HJ, Li HQ, Qin S, Wang YE, Li J, Lou HF, Chen Z, Li XM, Luo QM, Duan SM. Microglial migration mediated by ATP-induced ATP release from lysosomes. Cell Research, 22(6),1022-33.62(2012). 

14. Wang YB, Wang JJ, Wang SH, Liu SS, Cao JY, Li XM, Qiu S, Luo JH. Adaptor protein APPL1 couples synaptic NMDA receptor with neuronal prosurvival phosphatidylinositol 3-kinase/Akt pathway. Journal of Neuroscience, 32(35),11919-29(2012). 

15. Zhong K, Wu DC, Jin MM, Xu ZH, Wang Y, Hou WW, Li XM, Zhang SH, Chen Z. Wide therapeutic time-window of low-frequency stimulation at the subiculum for temporal lobe epilepsy treatment in rats. Neurobiology Disease, 48(1), 20-6(2012).

通訊作者:

1. Zhu JM, Li KX, Cao SX, Chen XJ, Shen CJ, Zhang Y, Geng HY, Chen BQ, Lian H, Zhang JM, Li XM*. Increased NRG1-ErbB4 signaling in human symptomatic epilepsy. Scientific Reports, 7: 141 (2017).

2.Pan G, Yang JM, Hu XY, Li XM*. Postnatal development of the electrophy -siological properties of somatostatin interneurons in the anterior cingulate cortex of mice. Scientific Reports. 6:28137 (2016).

3. Zhang Y, Cao SX, Sun P, He HY, Yang CH, Chen XJ, Shen CJ, Wang XD, Chen Z, Berg DK, Duan SM, Li XM*. Loss of MeCP2 in cholinergic neurons causes part of RTT-like phenotypes via the α7 receptor in the hippocampus. Cell Research, 26(6):728-42 (2016).
4. Ni KM, Hou XJ, Yang CH, Dong P, Li Y, Zhang Y, Jiang P, Berg DK, Duan SM, Li XM*. Selectively driving cholinergic fibers optically in the thalamic reticular nucleus promotes sleep. eLife, 5. pii: e10382 (2016).
5. Pan G, Li Y, Geng HY, Yang JM, Li KX, Li XM*, Preserving GABAergic interneurons in acute brain slices of mice using the N-methyl-D-glucamine-based artificial cerebrospinal fluid method. Neuroscience Bull, 31(2),265-70(2015).
6. Lu YM, Gao YP, Tao RR, Liao MH, Huang JY, Wu G, Han F, Li XM*, Calpain-dependent ErbB4 cleavage is involved in brain ischemia-induced neuronal death. Molecular Neurobiology, 53(4):2600-9 (2015).
7. Yang JM, Zhang J, Yu YQ, Duan SM, Li XM*, Postnatal development of 2 microcircuits involving fast-spiking interneurons in the mouse prefrontal cortex. Cerebral Cortex, 24(1),98-109(2014).
8. Hou XJ, Ni KM, Yang JM, Li XM*, Neuregulin 1/ErbB4 enhances synchronized oscillations of prefrontal cortex neurons via inhibitory synapses. Neuroscience,261,107-117(2014).

9. Yang JM, Zhang J, Chen XJ, Geng HY, Ye M, Spitzer NC, Luo JH, Duan SM, Li XM*. Development of GABA circuitry of fast-spiking basket interneurons in the medial prefrontal cortex of erbb4-mutant mice. Journal of Neuroscience, 33(50),19724-19733(2013).
10. Li KX, Lu YM, Xu ZH, Zhang J, Zhu JM, Zhang JM, Cao SX, Chen XJ, Chen Z, Luo JH, Duan SM, Li XM*, Neuregulin1 signaling regulates excitability of fast-spiking interneurons via Kv1.1 and acts Epilepsy. Nature Neuroscience, 15(2),267-273(2012).

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